BindingDB BDBM79181 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::MLS001146870::SMR000059133::TRIFLUOPERAZINE::TRIFLUOPERAZINE DIHYDROCHLORIDE::Trifluperazine::US11542290, Compound Trifluoperazine::cid_2913535::cid

BDBM79181 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::MLS001146870::SMR000059133::TRIFLUOPERAZINE::TRIFLUOPERAZINE DIHYDROCHLORIDE::Trifluperazine::US11542290, Compound Trifluoperazine::cid_2913535::cid_5566

SMILES CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1

InChI Key InChIKey=ZEWQUBUPAILYHI-UHFFFAOYSA-N

Data 71 KI 22 IC50 6 Kd

PDB links: 7 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 79181

Ubiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM79181(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)

IC50: >2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair

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Filter my 99 hits

Targets 43▿
- D(2) dopamine receptor 15
- D(4) dopamine receptor 6
- Alpha-1A adrenergic receptor 5
- 5-hydroxytryptamine receptor 2A 5
- Calmodulin-1 4
- Histamine H1 receptor 4
- 5-hydroxytryptamine receptor 2C 4
- 5-hydroxytryptamine receptor 7 4
- ATP-dependent translocase ABCB1 4
- 5-hydroxytryptamine receptor 6 3
- Alpha-2A adrenergic receptor 3
- Protein kinase C zeta type 2
- Sigma non-opioid intracellular receptor 1 2
- Dopamine receptor D4 2
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 2
- 5-hydroxytryptamine receptor 1A 2
- Serotonin 2 (5-HT2) receptor 2
- D(1A) dopamine receptor 2
- Muscarinic acetylcholine receptor M2 2
- Calmodulin 2
- Bile salt export pump 2
- C-8 sterol isomerase ERG2 1
- Pleiotropic ABC efflux transporter of multiple drugs 1
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- WD repeat-containing protein 48 1
- 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
- Alpha-2B adrenergic receptor 1
- Calcium-dependent protein kinase 4 1
- Albumin 1
- DNA-dependent protein kinase catalytic subunit 1
- Genome polyprotein 1
- Muscarinic acetylcholine receptor M3 1
- Alpha-2C adrenergic receptor 1
- D(3) dopamine receptor 1
- Beta-glucuronidase 1
- Emopamil-binding protein-like 1
- Lysozyme C-1 1
- NADPH oxidase 1 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 1
- Ubiquitin-conjugating enzyme E2 N 1
- Trypanothione reductase 1
- ...
Publications 45▿
- Neuropsychopharmacology 28: 519-26 (2003) 12
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- J Med Chem 35: 552-8 (1992) 5
- J Pharmacol Exp Ther 268: 1403-10 (1994) 5
- Eur J Pharmacol 103: 197-204 (1984) 5
- Mol Psychiatry 3: 123-34 (1998) 4
- J Med Chem 29: 359-69 (1986) 4
- Psychopharmacology (Berl) 120: 365-8 (1995) 3
- Biochem Biophys Res Commun 289: 580-5 (2001) 3
- US Patent US11542290 (2023) 3
- J Med Chem 48: 4754-64 (2005) 3
- Neuropsychopharmacology 16: 93 (1997) 3
- Nature 350: 610-4 (1991) 2
- Eur J Pharmacol 236: 483-6 (1993) 2
- Eur J Med Chem 116: 36-45 (2016) 2
- J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) 2
- Mol Pharmacol 13: 454-73 (1977) 2
- Bioorg Med Chem Lett 14: 1011-4 (2004) 2
- Br J Pharmacol 115: 107-16 (1995) 2
- Mol Pharmacol 12: 800-12 (1976) 2
- J Pharmacol Exp Ther 282: 1011-9 (1997) 2
- J Pharmacol Exp Ther 295: 226-32 (2000) 1
- Synapse 25: 137-46 (1997) 1
- J Med Chem 48: 1-20 (2005) 1
- J Med Chem 41: 148-56 (1998) 1
- Antimicrob Agents Chemother 53: 1516-27 (2009) 1
- Synapse 38: 438-49 (2000) 1
- PubChem Bioassay (2011) 1
- Bioorg Med Chem 21: 215-22 (2012) 1
- Bioorg Med Chem Lett 22: 5352-9 (2012) 1
- J Med Chem 63: 1937-1963 (2020) 1
- J Med Chem 61: 8061-8077 (2018) 1
- J Med Chem 45: 5671-86 (2002) 1
- J Med Chem 59: 9321-9336 (2016) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- Bioorg Med Chem Lett 9: 2279-82 (1999) 1
- J Nat Prod 56: 1805-10 (1993) 1
- J Med Chem 28: 381-8 (1985) 1
- PubChem Bioassay (2010) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- Drug Metab Dispos 39: 312-21 (2011) 1
- J Neurochem 66: 47-56 (1996) 1
- Hepatology 60: 1015-22 (2014) 1
- J Pharm Pharmacol 38: 374-9 (1986) 1
- J Med Chem 51: 3081-93 (2008) 1
Institutions 30▿
- Case Western Reserve University 20
- TBA 14
- Mayo Clinic 12
- University of Toronto 10
- R. W. Johnson Pharmaceutical Research Institute 5
- Camp4 Therapeutics 3
- Schering-Plough Research Institute 3
- University Of Innsbruck 3
- Syntex Discovery Research 2
- Kaohsiung Medical University 2
- Astrazeneca 2
- Maryland Psychiatric Research Center 2
- Purdue University 2
- Neurogen 2
- Universit£ 2
- Wroclaw Medical University 1
- University Of Chemistry And Technology Prague 1
- Albany Medical College 1
- University of North Texas 1
- Pfizer 1
- The Scripps Research Institute Molecular Screening Center 1
- University Of Connecticut Health Center 1
- Glaxosmithkline 1
- University Of Wollongong 1
- University Of Manchester 1
- Burnham Center For Chemical Genomics 1
- University of Washington 1
- Bulgarian Academy Of Sciences 1
- Key Laboratory Of Radiopharmaceuticals (Beijing Normal University) 1
- Semmelweis University 1
Affinity: 0.19 to 5.0E+5 nM▿
- Ki 71
- IC50 22
- Kd 6
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1